Setup that works for my brain but hopefully it can help you as a template to organize your own bars. 

ACTION BAR 1:
---------------------------------------------------------------------
TOP ROW - CTRL

MIDDLE ROW - SHFT

BOTTOM ROW - 1, 2, 3, 4


ACTION BAR 2:
---------------------------------------------------------------------
TOP ROW - CTRL

MIDDLE ROW - SHFT

BOTTOM ROW - Q,E,R,X



ACTION BAR 3:
---------------------------------------------------------------------
TOP ROW - CTRL

MIDDLE ROW - SHFT

BOTTOM ROW - F,C,V,T

Yes, I should get a MMO mouse some day :)

The bottle macro is a replacement for my DEX pots!

stegia