I show Cross Hotbar 3 (Left) with both of the expanded trigger controls, so you can easily add in another 8 actions if you prefer, I use XHB 8 as a shared bar between all classes for traversal and general actions outside of combat. Role actions are consistent among my layouts, and so are general actions. The macro icon is a placeholder for a Tincture/Gemdraught.

Single target on chotbar 1, AoE on chotbar 2. I change using the right bumper button (R1) and sit on the chotbar as needed. Possibly based on Squintina's layout with tweaks, I can't remember if I got my original layout from her or not.

Not updated for 7.0. Putting this up for a friend (and so I can transfer my chotbar to my alts)

Single Target (L)

Mobs (R)

My personal XHB for raiding Extreme, Savage and Ultimate. But also works for normal use.

Bar 1: single target Bar 2: AOE Bar 3: XHB

Puts most of the strain on the left hand, and off of the right.

Single target on right, AOE on left, dances and buffs on cross.

for each job, I create a "hotbar" that is basically a monitor for any spell/skill/cooldowns I want to see the status of; I also have a hotbar with Role spells & skills, and, Sprint. These are the spells I have for Dawntrail. I use Hotbars 2 & 10 but you can use any Hotbars you want.

Updated for Dawntrail

Buttons consistent for similar job actions (Dye = Potion)

Valen Bree

MMO mouse setup with modifiers.

Waiting for the new action images to get added in to fully get this good

Make sure to change Double tap L2 to "Cross Hotbar 4 - Left" and Double tap R2 to "Cross Hotbar 4 - Right"